氟哌酸β-环糊精包结配合物的研究

STUDIES OF NORFLOXACIN WITH β CYCLODEXTRIN INCLUSION COMPLEX

氟哌酸是一种广谱、安全、有效，可供口服的抗感染药．我们通过荧光光谱、１ＨＮＭＲ、１３ＣＮＭＲ等技术对氟哌酸与β－环糊精（β－ＣＤ）的相互作用进行了研究，证明氟哌酸和β－ＣＤ形成了包结配合物．包结配合物的生成常数由１ＤＮＭＲ和荧光光谱测量而确定，并由改进的Ｂｅ－ｎｅｓｉ－Ｈｉｌｄｅｂｒａｎｄ方法进行了计算。

The norfloxacin is an effective and safe anti infective with broadspectrum, and can be taken orally. The interaction of norfloxacin with β CD has been studied by several analytical techniques, including 1D 1H NMR, 13 C NMR, and fluorescence spectra. The experimental results confirmed the existence of a 1∶1 inclusion complex of norfloxacin and β CD. The formation constant of the complex was determined by use of 1D NMR data, a modified Benesi Hildebrand procedure was employed to calculate the formation constant. A spacial configuration of the complex has been proposed based on these date.