3-氧,11α-羟基、Δ^(12)-齐墩果烯及其类似化合物的^(13)C NMR分析

13 C NMR ANALYSIS OF 3 OXE,11 HYDROXY OLEAN 12 ENE AND ITS ANALOGUE

化合物１－８属于近似结构的齐墩果烷型三萜，它们分别为：β－ａｍｙｒｉｎ（１）；３－氧，Δ１１，１３（１８）－齐墩果二烯（２）；３β－羟基，Δ１１，１３（１８）－齐墩果二烯（３）；３β，２４－二羟基，Δ１１，１３（１８）－齐墩果二烯（４）；３，１１－二氧，Δ１２－齐墩果烯（５）；３－氧，Δ９（１１），１２－齐墩果二烯（６）；３－氧，１１α－羟基，Δ１２－齐墩果烯（７）；３β，１１α－二羟基，Δ１２－齐墩果烯（８）．它们的１３ＣＮＭＲ化学位移归属已确定，并通过了ＤＥＰＴ谱的验证．按结构特点分为三组：２～４为第一组，１，５，７，８为第二组，６为第三组．本文重点讨论了它们的１３ＣＮＭＲ化学位移由其结构特点引起的变化，得到了化学位移与结构相关的有意义的结果．

Compounds 1-8 belong to oleanane type triterpenoids with similiar structures, 13 C NMR spectra of β amyrin (1); 3 oxo olean 11,13(18) diene (2); 3β hydroxy olean 11,13(18) diene (3); 3β,24 dihydroxy olean 11,13(18) diene (4); 3,11 dioxo olean 12 ene (5); 3 oxo olean 9(11),12 diene (6); 3 oxo, 11α hydroxy olean 12 ene(7); 3β,11α dihydroxy oean 12 ene (8) were studied, and spectral assignments were carried out. The assignments were checked by their DEPT spectra. They were divided into three guoups, 2 4 in the first guoup; 1,5,7,8 in the second and 6 in the third. This paper investigated and discussed mainly the changes of their 13 C NMR chemical shift values which were taken place by the structural characterization and substituted groups. Some significant results of chemical shifts in relation to structures were obtained.