哈萨克族原发性高血压患者血浆视黄醇结合蛋白4水平及其相关性研究

Plasma level of retinal binding protein 4 and its correlation in patients with essential hypertension of Kazakarts.

目的分析新疆哈萨克族（哈族）原发性高血压（EH）患者血浆视黄醇结合蛋白4（RBP4）水平及其与血压、血脂、血糖、胰岛素及胰岛素抵抗指数（HOMA-IR）的关系。方法以2008年8月至11月流行病学调查的新疆哈族人81例为研究对象。哈族EH患者41例为病例组，哈族健康人群40例为对照组。测量血压，测定血浆RBP4、胰岛素、血糖、TC、TG、HDL—C、LDL—C、载脂蛋白A1和载脂蛋白B，计算HOMA-IR。结果①EH组血浆RBP4水平明显高于对照组[（32．74±9．93）mg/L与（21．92±10．43）mg／L，P〈0．01]；②EH组血浆RBP4与年龄、收缩压、舒张压、血糖、HOMA—IR呈显著正相关（rs=0．618、0．775、0．565、0．317、0．369，P〈0．01或P〈0．05）；在对照组中，RBP4与血糖呈正相关（rs=0．414，P〈0．01）。③多元回归分析显示：EH组收缩压（标准化偏回归系数0．591，t=5．695，P=0．000）进入回归方程，是影响血浆RBP4水平的独立因素。结论哈族EH患者血浆RBP4水平升高，并与收缩压、舒张压、血糖、HOMA-IR呈显著正相关，RBP4可能通过促进胰岛素抵抗而参与了EH的发生、发展。

Objective To explore the plasma level of retinol binding protein 4 （RBP4） in patients with essential hypertension （EH） of Xinjiang Kazakans and the relations between plasma RBP4 level and blood pressure, blood lipids,blood glucose, insulin, and HOMA-IR. Methods 81 Kazakans eases who were investigated between August and November of 2008 were selected as subjects. They were divided into EH group（ n = 41 ）and control group （n = 40）. Blood pressure was measured. Fasting venous blood was drawn to detect the plasma RBP4 ,fasting insulin （ FINS）, fasting plasma glucose （ FPG）, total cholesterol （ TC ）, triglyceride （ TG）, high density lipoprotein cholesterol （ HDL-C ） ,low density lipoprotein cholesterol （ LDL-C ）, apoprotein-A1 （ Apo-A1 ） and apoprotein-B （ Apo-B ）, and homeostasis model assessment of insulin resistance index（HOMA-IR） was calculated. Results ①The plasma RBP4 concentration in EH group was significantly higher than that in control group[ （32.74 ±9.93） mg/L vs （21.92 ± 10.43 ）mg/L,P = 0.01 ]. ①RBP4 was positively correlated with age, systolic blood pressure （SBP）, diastolic blood pressure （DBP） ,FPG,and HOMA-IR in EH group （rs=0. 618,0. 775,0. 565,0. 317,0. 369,P 〈 0.01 or P 〈 0.05 ）, and positively correlated with FPG in control group （ rs = 0. 414, P 〈 O. 01 ）. ③Multiple regression analysis showed that SBP was independent factor to affect the RBP4 level in EH group（ Standardized Coefficients is 0.591, t = 5. 695,P = 0.000）. Conclusion The plasma RBP4 concentration is increased in patients with EH of Kazakans , and is positively correlated with SBP, DBP , FPG, HOMA-IR in EH group. RBP4 may involve in the development of EH by promoting insulin resistance.