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TCR基因突变分析技术作为生物剂量计的研究进展 被引量：1

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摘要 随着核科学的进步和核技术的发展，以及放射性同位素的广泛应用，放射医学及其相关学科得以迅速发展，同时电离辐射可能带来的危害也成为不容忽视的问题。特别是近年来放射事故和核恐怖事件的发生，使得事故后损伤程度的判断及救治极为重要。这就需要了解和确定受辐射照射的剂量，现有的方法主要有物理、生物和临床的方法。物理剂量计较为准确、可靠，但是由于佩戴不便等缺点不适用于特殊条件下的佩戴要估算急性突发事故的辐射剂量，生物学方法是利用生物体标本在电离辐射后留下的辐射特异性损伤，根据实验中得到的剂量-效应曲线推断辐射剂量的方法。此种方法具有直接性等优势。其中，染色体畸变分析和淋巴细胞微核技术较为成熟，但在具体应用中适用剂量范围局限，不适于对受照群体进行大规模的检测。
作者 石燕 刘伟 侯殿俊
机构地区 山东省医学科学院放射医学研究所
出处 《中国辐射卫生》 2009年第2期249-251,共3页 Chinese Journal of Radiological Health
关键词 生物剂量计 基因突变分析 TCR 剂量-效应曲线 染色体畸变分析 放射性同位素 电离辐射 放射事故
分类号 R144.1 [医药卫生—公共卫生与预防医学] R733.72 [医药卫生—肿瘤]
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参考文献17

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二级参考文献10

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共引文献6

同被引文献8

  • 1安艳.电离辐射生物剂量学方法研究进展[J].中国辐射卫生,2006,15(1):109-112. 被引量：2
  • 2陈国千,邹荣良.胞外高迁移率族蛋白B1的研究进展[J].国际检验医学杂志,2006,27(4):344-346. 被引量：8
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  • 6Waterer GW.High-mobility group box 1 (HMGB1) as a potential therapeutic target in sepsis-more questions than answers.Crit Care Med,2007,35(4):1205-1206.
  • 7Schildkopf P,Frey B,Mantel F,et al.Application of hyperthermia in addition to ionizing irradiation fosters necrotic cell death and HMGB1 release of colorectal tumor cells.Biochem Biophys Res Commun,2010,391 (1):1014-1020.
  • 8周艳萍.酶联免疫吸附试验检测法的质量控制[J].检验医学与临床,2009,6(14):1206-1207. 被引量：7

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中国辐射卫生
2009年 第2期

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