中西医结合治疗儿童慢性特发性血小板减少性紫癜

Evaluate the Clinic Effect of Integrated Traditional and Western Medicine on Treating Child Chronic Idiopathic Thrombocytopenic Purpura

目的:探讨中西医结合疗法治疗儿童慢性特发性血小板减少性紫癜的临床效果。方法:将40例儿童慢性特发性血小板减少性紫癜患者按就诊顺序分为治疗组(中药汤+泼尼松片)及对照组(长春新硷+泼尼松片),治疗6个月后观察出血症状、血小板计数、肝肾功能改变及巨核细胞形态及比例变化。结果:治疗组总有效率为86.4%,对照组总有效率为55.6%,差异有显著性(P<0.05)。治疗组治疗期间肝肾功能副作用明显少于对照组(P<0.05),且血小板及巨核细胞回升亦较对照组快。结论:中药汤剂加皮质激素治疗慢性ITP疗效优于传统激素加免疫抑制剂,且肝肾功能损害明显减少,值得推广。

Objective：To evaluate the clinic effect of integrated traditional and western medicine on treating child chronic idiopathic thromboeytopenic purpura （CITP）. Methods： 40 cases of CITP were divided into two groups according to the order of visit. Group of integrated traditional and western medicine were administrated Chinese herbs and dehydrocortisone, the other group were given vincristin and dehydrocortisone. Haemorrhage symptoms, platelet count, liver and renal function, morphous and ratio of giant plates were detected after 6 months treatment. Results： The effective rate of integrated traditional and western medicine and the other group was 86.3% and 55.5% respectively,The difference is singnificant（P 〈0.05）. Meanwhile, the liver and renal side effects caused by integrated traditional and western medicine was less than that of the other group （P 〈0.05）.Moreovcr, the number of plates and giant plates was increased fast in patients with traditional and western medicine treatment. Conclusion： Considering therapeutiet effect and side effects, Chinese herbs combined with cortieosteroids is better than immunosuppressive agent combined with corticosteroids.