系统性红斑狼疮并发股骨头坏死的介入治疗初探

Clinical Study on Interventional Therapy for Avascular Necrosis of Femoral Head in Patients with Systemic Lupus Erythematosus

目的:观察选择性动脉内药物灌注治疗系统性红斑狼疮并发股骨头坏死早期的中长期疗效。方法:10例系统性红斑狼疮经糖皮质激素后,依据Steinberg分期确诊为Ⅰ～ⅣB期的股骨头缺血性坏死的患者,均采用选择性旋股内动脉、旋股外动脉、闭孔动脉内灌注治疗,随访6至8月,Harris评分评价其治疗效果。结果:10例患者均有长期的疼痛减轻、患肢活动范围改善和无痛行走距离增加。结论:选择性动脉药物灌注治疗是有效的治疗早期激素性股骨头缺血性坏死的保守疗法。

Objective： To study the clinical effect of interventional therapy with medical perfusion for avascular necrosis of femoral head （ANFH） in patients with systemic lupus erythematnsus（SLE）. Methods： A total of 10 ANFH patients （14 hips）with SLE, who were diagnosed from I stage to IVA stage by Steinberg＇s Stages, were subjected to interventional therapy with medicine （uroki-nase and Notoginsenoside Injection） by selective medial femoral circumflex, lateral femoral circumflex artery and obturator artery. All patients were followed up for more than 6 months. Results： After treatment, hip pain and joint dysfunction were alleviated persistently, especially in patients at grade Ⅲ. The Harris＇ score was obviously better in patients after therapy than in those before therapy （P〈0.05）. Conclusion： Interventional therapy with medical perfusion is an effective method for the treatment of early ANFH in patients with SLE.