黄花倒水莲的化学成分

Chemical constituents from root of Polygala fallax

目的研究远志科远志属植物黄花倒水莲Polygala fallax根的化学成分。方法采用硅胶柱色谱、Sephadex L H-20柱色谱以及重结晶等方法，分离纯化黄花倒水莲的化学成分，通过波谱方法对结构进行解析和鉴定。结果确定了6个化合物的结构，分别为3-O-β-D—glucopyranosyl senegenic acid（Ⅰ）、远志皂苷（tenuifolin，Ⅱ）、细叶远志皂苷元（presenegenin，Ⅲ）、1，7-二甲氧基-2，3亚甲二氧基仙酮（1，7-dimethoxy-2,3-methyienedioxy xanthone，Ⅳ）、芥子酸（sinapinicacid，Ⅴ）、阿魏酸（ferulic acid，Ⅵ）。结论化合物Ⅲ～Ⅵ为首次从该种植物中分离得到，化合物Ⅰ为首次从该植物中发现的远志酸型皂苷，且为新化合物，命名为黄花倒水莲皂苷A（fallaxsaponin A）。

Objective To investigate the chemical constituents of Polygala fallax. Methods The chemical constituents were isolated and purified via silica gel and Sephadex LH-20 column chromatography as well as recrystallization. Their structures were determined on the basis of spectral analysis and physicochemical properties. Results Six compounds were isolated and identified as 3-O-β-D-glucopyranosyl senegenic acid （ Ⅰ ）, tenuifolin （Ⅱ）, presenegenin （ Ⅲ ）, 1, 7-dimethoxy-2, 3-methylenedioxy xanthone （Ⅳ）, sinapinic acid （ Ⅴ ）, ferulic acid （Ⅵ）. Conclusion Compounds Ⅲ- Ⅵ are isolated from P. fallax for the first time. Compound I is a new triterpenoid saponin, named fallaxsaponin A.