锌制剂在小儿游走性舌炎治疗中的意义

The signification of the zinc preparation in the treatment of the children's migratory glossitis

目的研究地图舌与微量元素的关系，及用含锌制剂治疗前后微量元素的变化情况。方法随机选取41例1—6岁地图舌患儿作为实验组，50例1～6岁正常儿童作为对照组，分别采集实验组和对照组儿童的血清，用火焰原子化分光光度法测定微量元素；用含锌制剂治疗41例地图舌患儿，观察治疗效果并随访六个月后再次测定其血清微量元素的含量。结果治疗前实验组比对照组血锌含量低，血清铜含量高，差异具显著性（P〈0．001，P〈0．05）；血清铁、镁含量的差异无显著统计学意义（P〉0．05）。六个月后跟治疗前相比，实验组血锌含量升高，血清铜含量降低，差异具显著性（P〈0．001，P〈0．05）。六个月后，实验组跟对照组血清微量元素的差异均无显著性（P〉0．05）。结论微量元素锌缺乏，铜含量的增高可能是游走性舌炎的一个重要病因，临床上补充锌能有效治疗小儿游走性舌炎。

Objective To study the relationship between the geographic tongue and the mieroelements and the changes of microelements before and after treatments. Methods The test group included 41 children （ 1 - 6 years old） and the control group, 50 children （ 1 - 6 years old）. Blood was drawn from all the children and serum was separated and microelements were detected by flame atomization absorption spectrometry; The 41 patients received the zinc preparation treatment and a follow up for 6 months. Then microelements detection was performed. Results There were significant differences of the contents of serum zinc and copper between the test group and the control group （ P 〈 0. 001, P 〈 0.05, respectively） before the treatment. And there was no significant difference of the contents of the serum iron and magnesium between the test group and the control group （P 〉 0.05） before the treatment. The concentration of serum zinc increased and the copper concentration decreased after 6 months＇ treatment and the differences between before and after treatment showed significant （P 〈 0. 001, P 〈 0.05, respectively）. There was no statistical significance of the serum microelements between the test group and the control group （P 〉 0.05 ） after 6 months treatment. Conclusion Short of zinc and too much copper may be one of the important causes of migratory glossitis. Geographic tongue can be treated effectively by the zinc preparation clinically.