2001～2008年成都市青白江区出生缺陷监测结果分析

Analysis of Monitoring Results of Birth Defects in Qingbaijiang District of Chengdu from 2001 to 2008

目的：了解成都市青白江区出生缺陷的发生率、疾病顺位及影响因素，制定相应干预措施，降低出生缺陷率，提高人口素质。方法：按照全国出生缺陷监测中心制定的监测方案，采用流行病学前瞻性研究方法，对2001～2008年围产儿出生缺陷情况进行分析。结果：22406例围产儿出生缺陷242例，出生缺陷发生率10．80‰，出生缺陷前3位依次为多（并）指（趾）、总唇裂、耳部畸形；出生缺陷发生率呈逐年上升趋势，乡村明显高于城镇（P〈0．05），产母年龄≥35岁者出生缺陷发生率明显增高（P〈0．05），出生缺陷发生率与新生儿性别无相关性（P〉0．05）。结论：广泛开展优生优育宣传教育，加强婚前及孕期保健工作，提高产前检查技术，降低出生缺陷发生率和围产儿死亡率。

Objective：To study the incidence of birth defects, the disease sequence and influencing factors in Qingbaijiang and formulate a intervention measure for depressing the incidence of birth defects and improving the quality of the population. Methods：According to the monitoring plan of National Birth Defects Monitoring Center, from 2001 -2008 with a epidemiologic study to analyse perinatal birth defects. Results：The incidence of birth defects was 10. 80% （242/22 406）. The top 3 in order of birth defects were the multiple （merging）fingers （toes）, cleft palate and ear malformation in turn. The incidence was rising year by year. The incidence in rural was obviously higher than in town（ P 〈 0. 05 ）. The incidence of birth defects in the group of parturient aged exceeds 35 years was significantly higher（ P 〈 0. 05 ）. There was no associativity between babies sex and incidence of defects （ P 〉 0.05 ）. Conclusion： It can reduce the incideuce of birth defects and perinatal motality to publicize extensively the education of healthy birth and child care, strengthen the health care work of premarital and pregnancy, improve antenatal examination technology.