大肠埃希菌耐药性对尿路感染抗菌治疗的影响

The effects of antibiotics resistant Escherichia coli on urethral infection

目的了解本地区尿路感染中大肠埃希菌的病原分布和细菌产生耐药的原因,分析耐药菌株对尿路感染患者抗菌治疗的影响。方法对5年来由大肠杆菌引起的尿路感染患者细菌的耐药状况及对抗菌治疗的影响因素进行分析。结果本地区大肠埃希菌在尿路感染中占第1位。超广谱β-内酰胺酶(ESBL)平均发生率40.98%,ESBL+大肠埃希菌对喹诺酮类药物耐药达约90%,对常用抗菌药物呈多重耐药状态。结论大肠埃希菌仍是尿路感染主要病原菌,耐药的主要表现形式是ESBL,ESBL+大肠埃希菌对常见抗菌药物耐药严重,所致尿路感染的抗菌治疗更为棘手。

Objective To reveal the distribution of the Escherichia coli for urethral infection in the region and the cause of antibiotic tolerance, and analysis the effects of antibiotics resistant stems of Escherichia coli on urethral infection. Methods TO analysis the status of antibiotics resistant Escherichia coli for urethral infection for rescent years and factors of antibiotics treatment. Results Escherichia coli is the number 1 of the pathogens for urethral infection. The presence of ESBL is 40. 98% , and the ratio of tolerance to ESBL and Escherichia coli is above 90%. Several antibiotics resistant Escherichia coli presents. Conclusion Escherichia coli is the main pathogen to the urethral infection, mechanism of tolerance is ESBL, high degree resistant ESBL and Escherichia coli is present. So the efficiency of antibiotics for urethral infection is unfavourable.