高压氧综合治疗新生儿缺氧缺血性脑病临床分析

A clinical analysis of combined therapy for 253 cases of neonatal hypoxic and ischemic encephalopathy

目的观察并总结高压氧治疗新生儿缺氧缺血性脑病(HIE)的临床疗效。方法随机将HIE195例分为2组,治疗组150例,对照组45例;2组新生儿均在对症、支持、恢复脑细胞等基础治疗上,治疗组给予高压氧治疗,并进行6个月的随访观察。结果治疗组预后良好136例(90.67%);对照组预后良好19例(42.22%)。治疗组与对照组的预后差异有统计学意义(P<0.01)。结论高压氧综合治疗对改善HIE患儿预后有显著效果。

Objective To observe and summarize the therapeutic effects of hyperbaric oxygen therapy on neonatal hypoxic and ischemic encephalopath （HIE）. Methods 195 neonates with HIE were randomly divided into treatment group and control group. 45 neonates with HIE in control group were treated by basic expectant treatment., supporting therapy and recovery of cerebral cell, however, the 150 neonates in treatment group ,on the basis of control group, were treated by hyperbaric oxygen therapy and were followed up for 6 months. Results Among 150 neonates in treatment group, 136 cases （90.67%） had better prognosis, while among 45 neonates in control group, 19 cases（42.22% ） had better prognosis, there was a significant difference between two groups （ P 〈0.01 ）. Conclusion The hyperbaric oxygen combined treatment can improve the prognosis in neonates with HIE.