CRP浓度评价急性前壁心肌梗死后左心室重塑和心功能的临床研究

The study on the CRP concentrations in evaluation of left ventricular remodeling and heart function after AMI

目的探讨血浆C-反应蛋白(C-reactive protein,CRP)浓度在评价急性心肌梗死(acute myocardial infarction,AMI)后左心室重塑和心功能方面的价值。方法测定首次前壁AMI患者发病后血浆CRP的浓度,并进行超声心动图检查,测定左心室舒张末期内径和左心室射血分数(left ventricular ejection fraction,LVEF),根据计算出的左心室舒张末期容积指数增加率(ΔLVEDVI)将患者分为左心室重塑组和无左心室重塑组。结果AMI后左心室重塑组血浆CRP的峰值水平为(119±46)mg/L,高于无左心室重塑组的(70±31)mg/L,差异有统计学意义(P<0.05);左心室重塑组血浆CRP的峰值水平与ΔLVEDVI呈正相关(P<0.01),与LVEF呈负相关(P<0.01),且其相关性高于无左心室重塑组。结论CRP水平可作为评价AMI后左心室重塑和心功能的一种简单易行的指标。

Objective To investigate the clinical significance of the plasma concentration of C-reactive protein （CRP） in left ventricular remodeling （LVR） and heart function after AML Methods The levels of plasma CRP concentration were determined in patients after AMI. Left ventricular end diastolic diameter and left ventricular ejection fraction （LVEF） were measured by echocardiography. The patients were divided into two groups according to the levels of ALVEDVI： LVR group and non-LVR group. Results The peak concentration of CRP in LVR group was higher than that of non-LVR group （ 119 ± 46 vs 70 ± 31 ） mg/L（ P 〈0. 05）. There was a significant positive correlation between the levels of CRP and ALVEDVI in LVR group （ r = 0.68, P 〈0. 01 ） . There was a significant negative correlation between the levels of CRP and LVEF in LVR group （ r = - 0.50, P 〈 0. 01 ）. Conclusion The CRP levels can be used as an index in evaluating left ventricular remodeling and heart function after AMI.