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阿维A联合窄谱中波紫外线对银屑病患者炎症细胞因子的影响 被引量：4

Effect of Acitretin Combined Narrow-Band UVB on Expression of IL-6 and TNF-αin Psoriasis
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摘要 目的探讨阿维A联合窄谱中波紫外线(NB-UVB)治疗寻常性银屑病的疗效及其对炎症细胞因子白介素-6(IL-6)、肿瘤坏死因子(TNF-α)表达的影响。方法A组口服阿维A联合NB-UVB治疗,B组单纯口服阿维A,C组单纯用NB-UVB照射全身,14周后评价疗效并测定患者治疗前后血清中IL-6及TNF-α水平。结果A组总有效率明显高于其他组(P<0.05),血清中IL-6及TNF-α水平明显降低(P<0.05)。结论阿维A联合NB-UVB治疗银屑病,可提高疗效、缩短疗程,且能降低患者血清中IL-6及TNF-α水平。 Objective To observe the therapeutic effect of acitretin combing with narrow-band （NB） UVB phototherapy on psoriasis and the impacts on the expressions of IL- 6 and TNF- α. Methods The group A was given oral acitretin combined NB- UVB phototherapy; the group B received the mono-therapy of oral acitretin, the group C received the mono-therapy of NB- UVB. And the concentrations of IL- 6 and TNF- α in serum were arrayed by ELISA before and after therapy. Results The patients in group A were improved and the combination treatment had the better benefit, comparing with the group B （P 〈 0.05）. And the levels of IL- 6 and TNF- α in serum were decreased significantly （P 〈 0. 005）. Conclusion It is helpful for psoriasis therapy to systemically apply acitretin combined NB- UVB, by decreasing the side effects as well as decreasing the serum levels of IL- 6 and TNF- α.
作者 曾灶昌
机构地区 广东省深圳市光明新区公明医院
出处 《中国药业》 CAS 2009年第12期41-43,共3页 China Pharmaceuticals
关键词 阿维A 窄谱中波紫外线 银屑病 白介素-6 肿瘤坏死因子-Α alacitretin narrow - band UVB psoriasis IL - 6 TNF - α
分类号 R969.4 [医药卫生—药理学] R977.21 [医药卫生—药品]
  • 相关文献

参考文献9

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共引文献27

同被引文献48

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引证文献4

二级引证文献33

中国药业
2009年 第12期

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