口服和吸入激素联合治疗胸内结节病的肺功能对比观察

目的探讨吸入丙酸倍氯米松对胸内结节病患者肺功能改变的影响。方法回顾分析我院2002年1月至2007年6月收治的接受激素治疗的结节病患者42例,比较A组(单纯口服泼尼松治疗)和B组(口服泼尼松联合吸入丙酸倍氯米松治疗)治疗前后的肺功能。结果口服泼尼松联合吸入丙酸倍氯米松与单纯口服泼尼松相比,后者FEFmax%增长更明显,有统计学意义;而DLCO%两组治疗前后均有改善,差异无显著性。结论口服泼尼松联合吸入丙酸倍氯米松可能更有利于气道功能改善,且有助于减少口服激素剂量,减轻药物副作用。

Objective To analyze the influence of Pulmonary function of Inhaled beclometasome dipropionate in treatment of patients with sarcoidosis. Methods Clinical data of 42 patients with sarcoidosis from Junary 2002 to June 2007 were reviewed among patients with Group A（ orally received prednisome）and Group B（ orally received prednisome and inhaled beclometasome dipropionate）. Result The FEFmax% of latter was increased significantly, which has statistical significance, and the increased of DLCO% were not significantly different among the two groups. Conclusion Orally received prednisome and inhaled beclometasome dipropionate may be beneficial to improving the airway function, and it can reduce orally received prednisome dose and alleviate drug side effects.