恶性肿瘤术后化疗患儿医院感染危险因素的非条件Logistic回归分析

Logistic-regression Analysis of Risk Factors for Nosocomial Infection in Children Patients with Post-surgery Tumor Undergoing Chemotherapy

目的探讨恶性肿瘤术后化疗患儿医院感染的危险因素,为有效控制医院感染提供可靠依据。方法运用回顾性病例研究方法,调查医院儿科2004年12月-2008年12月恶性肿瘤术后化疗患儿312例,选择年龄、原发病、白细胞计数、医院感染情况等14个变量进行研究,对医院感染组和非感染组病例资料进行单因素χ2检验后,建立非条件Lo-gistic回归模型进行多元分析。结果312例患儿中发生医院感染86例,医院感染发生率为27.56%,多因素分析筛选出住院天数、外周血白细胞计数、中性粒细胞计数、侵入性操作是恶性肿瘤术后化疗患儿医院感染的独立危险因素。结论应尽量缩短住院时间、提高外周血白细胞和中性粒细胞计数、避免不必要的侵入性操作,以降低化疗患儿医院感染发病率。

OBJECTIVE To investigate the risk factors of nosocomial infection among child tumor patients with post-surgery chemotherapy. METHODS A total of 312 child tumor cases with post-surgery chemotherapy in the pediatric ward during from Dec 2004 to Dec 2008 were retrospectively reviewed. And 16 variables such as age, diagnosis, white blood cell count and nosocomial infections were studied. The data were analyzed with the single factorial X^2 test and multifactorial Logistic-regression analysis. RESULTS The incidence of nosocomial infection was 27.56%. The length of hospitalization, the white blood cell count, the neutrophil cell count and the invasive operation were found as independent risk factors of the nosocomial infection. CONCLUSIONS Shortening the hospitalization length, increasing the white blood cell and the neutrophil cell count and avoiding the unnecessary invasive operation will decrease the nosocomial infection.