195例成年人感染嗜血菌属药敏结果分析

Antibiotic Susceptibility of Haemophilus Species Isolated from 195 Adults

目的了解临床呼吸道感染患者嗜血菌属分离情况及对抗菌药物的敏感性,指导临床合理用药。方法2006-2007年临床痰液及咽拭子标本,采用巧克力培养基分离培养并鉴定嗜血菌属,检测产β-内酰胺酶阳性菌。结果分离到195株嗜血菌属,β-内酰胺酶阳性32株,占16.4%;药敏结果,对头孢呋辛、头孢噻肟和氨苄西林/舒巴坦的敏感率分别为90.8%、93.8%和95.4%。结论头孢噻肟、阿莫西林/克拉维酸、头孢呋辛为治疗嗜血菌属感染的首选药物。

OBJECTIVE To investigate the β-lactamases producing rate in Haemophilus influenzae（HIN） and the antibiotics sensitivity, to guide the treatment of Haemophilus species infection. METHODS The strains from respiratory tract samples, were isolated and cultivated in chocolate cultures 2006 to 2007. Drug sensitivity test and beta-lactam enzyme test of Haemophilus species were taken. The results were analyzed by software SPSSll. 5. RESULTS Totally 195 isolates of HIN were isolated 32 produced β-1actamases（16.4%）. The sensitivity of H. influenzae to cefuroxime, cefotaxime and ampicillin/sulbactam was 90. 8%, 93. 8% and 95. 4%, respectively. CONCLUSIONS Cefotaxime, ampicillin/sulbactam and cefuroxime are the most effective antibiotics for H. influenzae infection.