氟西汀联合小剂量喹硫平治疗难治性抑郁症效果评价

Fluoxetine plus small dose quetiapine in the treatment of refractory depression

目的评价氟西汀联合小剂量喹硫平治疗难治性抑郁症的临床疗效及安全性。方法对68例难治性抑郁症患者在原服用氟西汀治疗的基础上联用小剂量喹硫平治疗，观察8w。于治疗前及治疗1w、2w、4w、8w末采用汉密顿抑郁量表、临床疗效总评量表一疾病严重程度分量表评定临床疗效。结果治疗8w末痊愈率12．90％，总有效率为64．52％。治疗2w末起汉密顿抑郁量表、临床疗效总评量表-疾病严重程度分量表评分较治疗前显著下降（P〈0．01），并随治疗时间的延续均呈持续性下降。不良反应较轻微，耐受性好。结论氟西汀联合小剂量喹硫平治疗难治性抑郁症疗效显著，安全性高、依从性好。

Objective To evaluate the clinical efficacy and safety of fluoxetine plus small dose quetiapine in the treatment of refractory depression. Methods Sixty-eight refractory depression patients on fluoxetine were added small dose quetiapine to for 8 weeks. Clinical efficacies were assessed with the Hamilton Depression Scale（HAMD） and the Clinical Global Impression-Severity of Illness（CGI-SI） and adverse reactions with the Treatment Emergent Symptom Scale（TESS） before treatment and at the ends of the first, second ,foruth and eighth week treatment . Results At the end of the 8th week,cure rate was 12.90% and total effective rate 64.52%. The HAMD and CGI-SI score since the end of the 2nd week lowered more significantly compared with pretreatment （P〈0.01） and did continously along with time of therapy lasting; Adverse reactions were mild and tolerable. Conclusion Fluoxetine plus small dose quetiapine has an evident effect, higher safety and better compliance in the treatment of.