糖尿病终末期肾病长期血液透析预后因素的Cox模型分析

COX REGRESSION ANALYSIS IN RISK FACTORS OF LONG-TERM MAINTENANCE HEMODIALYSIS FOR END-STAGE RENAL DISEASE PATIENT

目的探讨糖尿病终末期肾病长期血液透析患者死亡的危险因素,为本病的防治提供参考依据。方法对85例糖尿病终末期肾病长期血液透析患者采用Cox模型回归法分析透析开始时各临床指标对生存时间的影响。结果在截尾和未截尾组中年龄、白蛋白、糖尿病病程、并发症个数等级、截尾时间差异有统计学意义,年龄、并发症个数等级、肌酐、白蛋白在Cox模型回归分析中有意义。结论年龄、并发症个数等级、白蛋白可能是糖尿病终末期肾病长期血液透析患者死亡的独立危险因素。

Objective To investigate the risk factors which might influence the mortality rate of the end - stage diabetic nephropathy （ESDN） patients treated with maintenance hemodialysis （MHD） and provide reference for the prevention and treatment. Methods Cox regression analysis of clinical data of 85 cases at the initial of long - term MHD for the ESDN was done to reveal the affection on survival time. Results There were statistical significance between censored group and uncensored group in age, serum albumin, duration of diabetes, grade of complications and censoring time. There were statistical significance with age, grade of complications, serum creatinine and serum albumin in Cox regression analysis. Conclusion The age,serum albumin and grade of complications may be the main risk death factors in ESDN treated with MHD.