帕金森病患者脑干听觉诱发电位的研究

The study of brain stem auditory evoked potential in Parkinson＇s disease

目的：探讨帕金森病（PD）患者脑干听觉诱发电位（BAEP）表现及其对PD的诊断意义。方法：PD组患者67例，并选择年龄、性别与之相匹配的30例正常人为正常对照，观察两组BAEP的差异。比较PD患者不同病程、统一帕金森病评定量表（UPDRS）的不同评分、Hoehn—Yahr（H—Y）的不同分期的BAEP的异同。结果：PD患者BAEP总异常率为23．9％，以Ⅰ-Ⅲ波间期（IPL）异常为主。PD组患者Ⅲ波、V波潜伏期（PL）、Ⅰ-ⅢIPL、Ⅲ-ⅤIPL、Ⅰ—ⅤIPL较对照组明显延长，差异具有统计学意义。而在PD组中，病程≥5年的患者Ⅰ—ⅤIPL较病程〈5年的患者明显延长，UPDRS得分≥36分的患者波ⅢPL较UPDRS得分％36分的患者明显延长，差异具有统计学意义。而不同H—Y分期患者BAEP比较，差异无统计学意义。结论：PD患者听觉传导通路存在异常，随着病程延长，UPDRS评分增高，BAEP更容易出现异常。

Objective：To study the brain stem auditory evoked protential（BAEP） of patients with Parkinson＇s disease（PD） and its assessment of utility in this disease. Methods： BAEP was observed in sixty-seven patients with PD and 30 gender-age matched normal controls and the difference between two groups was recorded. A second comparison was made in different cource,unified Parkinson＇s disease rating scale（UPDRS）,H-Y stages of patients with PD. Results： The abnormality rate of BAEP was 24%. The peak altency（PL） of Wave Ⅲ , Ⅴ and the interpeak latency （IPL） of Ⅰ-Ⅲ ,Ⅲ -Ⅴ and Ⅰ - Ⅴ were significantly prolonged in palients with Parkinson＇ s disease compared with the control group. Meanwhile the Ⅰ -Ⅴ IPL in a long course（≥5 years） with patients PD was prolonged compared with the short course（〈5 years） group. The Wave Ⅲ PL was prolonged in the higher UPDRS group（≥36） compared with the lower UPDRS group（〈36）. Thers is no difference between different H-Y stages. Conclusion： There was abnormality of auditory pathway in patients with PD and the Wave Ⅲ PL, the Ⅰ - Ⅴ IPL were prolonged with a longer course and higher UPDRS scores.