消融心房脂肪垫治疗心房颤动的研究现状

Ablation of Atrial Fat Pads to Treat Atrial Fibrillation

近年研究表明,迷走神经过度兴奋与一部分心房颤动的发生密切相关。由于支配心房的迷走神经丛主要分布于心房外膜的脂肪垫中,因此,以心房去迷走神经化为终点的脂肪垫消融成为一项新的心房颤动治疗措施。初步研究的结果显示,该术式治疗心房颤动确实有效,但同时也存在若干弊端。现就消融心房脂肪垫治疗心房颤动的现状作一综述。

Recent studies suggested that the over-excitement of vagus nerve system plays a critical role in the initiation of atrial fibrillation （ AF ）. While the vagal innervate the atrium mainly mediated by the epicardial fat pads （ FP）, ablation of FP with an endpoint of vagal denevation is becoming a new ablation strategy in treating AF. The results of the preliminary investigations not only provided much positive evidence favoring this emerging approach,but also highlighted its potential demerits so far. In this article, we review the current status of FP ablation in treating AF.