摘要
心房颤动是临床上最常见的心律失常之一,抗心律失常药物因效果不佳且不良反应多,使其在心房颤动的防治中应用有限。血管紧张素Ⅱ通过促进心房纤维化,缩短心房有效不应期,延长房室传导,诱导细胞内Ca2+超负荷及炎症反应等,促进心房的电重构及组织重构,从而在心房颤动的发生和维持中起积极作用。越来越多的研究表明血管紧张素Ⅱ受体拮抗剂在心房颤动的防治中具有广泛作用。
Atrial fibrillation is one of the most common arrhythmias in the clinical setting. The anti-arrhythmia drugs are limited to prevention and treatment, due to side effects and poor results. Angiotensin plays an active role in atrial fibrillation through promoting atrial fibrosis, shortening the atrial effective refractory period, extending atrioventricular conduction, inducing intra-cellular Ca^2＋ overloading, and inflammation, among others. An increasing number of studies show that the angiotensin receptor antagonist has a broad role in the prevention and treatment of atrial fibrillation. This article will review it＇s role.
出处
《心血管病学进展》
CAS
2009年第3期404-408,共5页
Advances in Cardiovascular Diseases
关键词
血管紧张素Ⅱ
血管紧张素Ⅱ受体拮抗剂
心房颤动
防治
angiotensin Ⅱ
angiotensin Ⅱ
receptor antagonist atrial fibrillation
prevention and treatment
