红细胞膜总胆固醇含量——急性冠状动脉综合征的一个新型标志物

Total Cholesterol Content of Erythrocyte Membranes:A New Marker of Acute Coronary Syndrome

急性冠状动脉综合征是由于纤维斑块破裂引发冠状动脉内血栓而导致的。斑块破裂部分上取决于坏死的脂质中心的大小,而红细胞转运胆固醇进入坏死中心则有助于脂质中心的增长。现对急性冠状动脉综合征和红细胞膜胆固醇的含量之间的关系进行了综述,探讨了红细胞膜胆固醇影响斑块稳定性的机制。红细胞膜胆固醇水平不仅仅反映了冠状动脉疾病活动性,而且也是急性冠状动脉综合征强的预测因子。

The disruption of the fibrous cap of vulnerable coronary atheromatous plaques leads to intracoronary thrombosis and acute coronary syndrome. Plaque rupture in acute coronary syndrome depends at least partly on the volume of the necrotic lipid core. The cholesterol transported by erythroeytes and deposited into the necrotic core of atheromatous plaques contributes to lipid core growth. In this text, we review the relationship between acute coronary syndrome and total cholesterol content of erythrocyte membranes, and discuss the mechanism that erythrocyte membranes ＇cholesterol affects the plaque instability. Total cholesterol content of erythrocyte membranes is not only a marker for coronary artery disease activity, but is a stronger predictor for acute coronary syndrome.