内皮脂肪酶与动脉粥样硬化的关系

Relationship of Endothelial Lipase and Atherosclerosis

内皮脂肪酶是脂肪酶家族新成员,最初发现在人脐静脉内皮细胞中表达,主要为磷脂酶活性,参与高密度脂蛋白为主的脂蛋白的代谢,其基因多态性与高密度脂蛋白胆固醇关系密切。内皮脂肪酶主要发挥致动脉粥样硬化功能,调节其表达与活性,可能为防治动脉粥样硬化带来益处。

Endothelial lipase （EL） is a novel member of the lipase family, whose expression was initially found in human umbilical vein endothelial cells. EL has mainly phospholipase activity, and primarily participates in high-density lipoprotein （ HDL） metabolism. The genetic polymorphism of EL is closely associated with HDL cholesterol concentrations. EL plays a significant role in atherosclerosis, and elevating HDL levels. The regulation of EL expression and activity may prevent atherosclerosis, and therefore may provide an effective therapy option.