102例恶性胸腔积液患者中医证候的临床分析

A Clinical Study on TCM Syndrome Patterns of 102 cases of Malignant pleural effusion(MPE)

目的:对恶性胸腔积液患者的中医证候进行分析。方法:选取确诊为恶性胸腔积液的102例患者的临床资料进行分析,录入证候四诊信息,采用描述性统计分析计算中医证候四诊指标频数及聚类分析(指标聚类及病例聚类)对患者的中医证候进行分析。结果:102例恶性胸腔积液患者聚类结果显示主要有以下四种证型:肺脾两虚,痰瘀互结证、脾肾两虚,痰饮犯肺证、气阴两虚,痰热犯肺证及阴虚内热,瘀毒内生证。四种证型分别占52.94%、28.43%、9.80%、8.82%。结论:恶性胸腔积液的患者多表现为虚实夹杂的证候,以单独实证或虚证难以概括整个证型。

Objective：To observe the distributing rule and diagnosis criterion of TCM syndrome of MPE, to providing basis of standardization of syndrome differentiation of MPE. Methods ： Adopt the prospect method, to collect the clinic data of MPE in our hospital,setting up databases,to analyze the TCM syndrome based on the description covariance and clustering analysis method. Results ：102 cases of MPE were observed,there are four TCM syndromes ,which are Asthenia of both lung and spleen,Accumulation of phlegm and stagnation （n =54,52.94% ） ; Asthenia of both kidney and spleen,attack on the lung by retained fluid（ n = 29,9. 80% ） ; Yin asthenia and heat,stagnation of virulent heat （n = 10,9. 80% ）, Asthenia of both qi and yin, Accumulation of phlegm and heat in lung （n =9,8.82% ）. Conclusion：In this data,TCM syndrome of MPE have certain regulation,often mixing up Asthenia and asthenia syndrome, which is different from pleural effusion caused by infection. The research result can provide a certain basis of standardization of TCM syndrome differentiation of MPE.