自身免疫性甲状腺疾病与肿瘤坏死因子-α/白细胞介素-6比值的关系研究

Researching on the relation between autoimmune thyroid disesae and tumor necrosis factors-alpha / interleukin-6 ratio

目的研究细胞因子与自身免疫性甲状腺病(AITD)中的关系。方法对71例Graves病(GD)、35例桥本甲状腺炎(HT)患者及36例对照者检测了血清中肿瘤坏死因子(TNF)-α、白细胞介素(IL)-6和甲状腺激素及相关抗体水平。结果各组TNF-α、IL-6显著高于对照组。GD组TNF-α/IL-6比值显著低于对照组,HT组TNF-α/IL-6比值显著高于对照组。结论Th1、Th2细胞因子共同参与AITD的发生发展过程。Th2介导的体液免疫在GD的病理反应中起主导作用;Th1介导的细胞免疫在HT的病理反应中起主导作用。

Objective To investigate the relation between sutoimmune thyroid disesae （AITD） and tumor necrosis factors-alpha-alpha （TNF-α） / Interleukin （IL）-6 ratio. Methods The level of TNF-α, IL - 6 and thyroid hormone were determined in 71 patients with graves＇disease （GD）, 35 patients with Hashimoto＇s thyroiditis （HT） and 36 control cases. Results Compared with the control, the level of TNF-α and IL-6 were significantly elevated in GD and HT groups, TNF-α/IL-6 ratio was significant decrease in GD and was significant elevated in HT. Conclusion Th2 mediated humoral immunity play a predominant role in GD. Th 1 mediated cell immunity play a predominant role in HT.