灯盏细辛注射液对血瘀型急性脑梗死患者VEGF及sICAM-1的影响

Effect of Erigeron Injection on VEGF and sICAM-1 in Acute Cerebral Infarction with Syndrome of Blood Stasis

目的探讨灯盏细辛注射液对血瘀型急性脑梗死患者血管内皮生长因子(VEGF)、可溶性细胞间黏附分子-1(sICAM-1)的影响,分析灯盏细辛注射液治疗急性脑梗死的作用机制。方法将符合选择标准的60例患者随机分为治疗组和对照组,并设立正常对照组30名,治疗组给予灯盏细辛静脉输注,对照组给予速避凝皮下注射;治疗前后分别检测VEGF、sICAM-1,并对患者的血瘀证积分、神经功能缺损积分等分别做出评定,分析其相关性。结果血瘀型急性脑梗死患者发病后,血清VEGF、sICAM-1含量显著高于健康人水平(P<0.05)。治疗后两组患者血清VEGF、sICAM-1的含量较治疗前均有显著性改善(P<0.01),但治疗组在治疗后VEGF增高更为明显(P<0.01)。血瘀型急性脑梗死患者血瘀证、神经功能缺损程度、血清sICAM-1含量三者之间存在显著正相关,而与血清VEGF则呈显著的负相关。结论血清VEGF、sICAM-1与急性脑梗死血瘀证密切相关。灯盏细辛能显著增高VEGF,明显抑制sICAM-1,改善ACI患者的脑血液循环,减轻脑组织缺血性损伤,是血瘀型脑梗死急性期安全有效的药物。

Objective To investigate the effect of erigeron injection on vascular endothelial growth factor （VEGF） and soluble intercellular adhesion molecule- 1 （sICAM- 1） in patients （pts） with acute cerebral infarction （ACI） and syndrome of blood stasis. Methods Sixty pts with ACI were randomly divided into treatment group （A group） treated with erigeron injection.control group （B group） treated with Fraxiparine. Thirty health subjects were as normal control group （C group）. The levels of blood serum VEGF and sICAM - 1 were measured before and after treatment. The integral of syndrome of blood stasis and neurological impairment were measured simuhaneously. The correlation of these indexes was analyzed. Results The serum levels of VEGF and sICAM - 1 in A and B two treatment groups were significantly higher than that in normal control group （P〈0.05）. After treatment, the levels of serum VEGF and sICAM - 1 were significantly improved （P〈0.01）. Following treatment, the level of VEGF in A group was increased more than that before treatment （P〈0.01）. There was significant positive correlation between the syndrome of blood stasis score, neurological impairment score and sICAM- 1 ,and there was negative correlation between these three indexes and VEGF. Conclusion The levels of VEGF, sICAM- 1 had close correlation with the syndrome of blood stasis. Erigeron injection could effectively reduce cerebral ischemie lesions and improve the cerebral blood circulation. It could effectively improve the level of VEGF and decrease the level of sICAM - 1. It was effective and safe medicine for the treatment of acute cerebral infarction.