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TEA及其同源类似物TPeA拮抗β淀粉样蛋白25-35引起皮层神经元细胞活力降低

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摘要 目的探讨TEA及其同源类似物TPeA对Aβ25-35所致的培养皮层神经元细胞毒性作用的影响。方法利用细胞毒性检测技术,如细胞活力检测cck-8、乳酸脱氢酶(LDH)释放检测和Calcein-AM染色,观察TEA及其同源类似物TPeA对Aβ25-35所致的培养皮层神经元细胞活力的影响。结果TEA及其同源类似物TPeA能够拮抗Aβ引起神经元死亡,包括Aβ引起细胞活力降低,LDH的释放增多,以及活细胞数目的减少。结论钾通道在Aβ引起神经元毒性作用中发挥重要作用,电压依赖性钾通道参与了Aβ引起的神经元死亡,钾通道可能成为防治神经退行性疾病的重要靶点。
出处 《中西医结合心脑血管病杂志》 2009年第6期684-686,共3页 Chinese Journal of Integrative Medicine on Cardio-Cerebrovascular Disease
基金 国家自然科学基金资助项目(No.30572085)
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