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宫颈阴道分泌物IL-8与早产的关系 被引量:3

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摘要 目的探讨宫颈阴道分泌物中的白细胞介素-8(IL-8)与早产的关系。方法收集42名妊娠28-36^+6周诊断为先兆早产的孕妇(研究组)和40名同期且孕龄相仿的正常孕妇(对照组)的宫颈阴道分泌物,采用ELISA法测定IL-8含量,并分析IL-8的预测价值及其与妊娠结局的关系。结果(1)研究组宫颈阴道分泌物IL-8水平明显高于对照组,差异有统计学意义(P〈0.05)。(2)以90 pg/ml为最佳临界点,宫颈阴道分泌物IL-8预测早产的敏感度、特异度、阳性预测值和阴性预测值分别为88.5%、84.3%、73.7%和91.5%。(3)IL-8阳性组与阴性组相比,阳性组的分娩孕周更小,取样至分娩的间隔时间更短,新生儿体质量更低。结论宫颈阴道分泌物IL-8与早产有相关关系,是预测早产较敏感的指标;IL-8阳性与不良妊娠结局有关。
作者 袁华 徐建英
出处 《苏州大学学报(医学版)》 CAS 北大核心 2009年第2期372-374,共3页 Suzhou University Journal of Medical Science
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