摘要
Thrombosis and in-stent restenosis constitute major clinical failures of endovascular stent implantation.In this research,a polyelectrolyte multilayered film of heparin/collagen was constructed onto the endovascular stent via layer-by-layer deposition.The in vitro human platelet adhesion test and blood clotting time assessments demonstrated that the fabricated multilayer took on excellent hemocompatibility.The in vitro human umbilical vein endothelial cell culture results show that the endothelial cell adhesion and proliferation are greatly promoted after the multilayer modification.Such multilayered endovascular stents with excellent hemocompatibilty and human endothelial cytocompatibility may have great potential in clinical applications.
Thrombosis and in-stent restenosis constitute major clinical failures of endovascular stent implantation. In this research, a polyeleetrolyte multilayered film of heparin/collagen was constructed onto the endovascular stent via layer-by-layer deposition. The in vitro human platelet adhesion test and blood clotting time assessments demonstrated that the fabricated muhilayer took on excellent hemocompatibility. The in vitro human umbilical vein endothelial cell culture results show that the endothelial cell adhesion and proliferation are greatly promoted after the multilayer modification. Such multilayered endovascular stents with excellent hemocompatibihy and human endothelial cytocompatibility may have great potential in clinical applications.
出处
《高等学校化学学报》
SCIE
EI
CAS
CSCD
北大核心
2009年第6期1256-1258,共3页
Chemical Journal of Chinese Universities
基金
国家“八六三”计划(批准号:2006AA03Z329)
国家“九七三”计划(批准号:2005CB623902)
浙江省科技计划(批准号:2007C24008)
吉林大学超分子结构与材料国家重点实验室开放课题基金(批准号:SKLSSM200712)资助
关键词
层层组装
细胞外基质
抗凝血
细胞相容性
Layer-by-layer
Extracellular matrix
Anti-thrombosis
Cytocompatibility
