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PcG蛋白EZH2与消化系肿瘤 被引量：1

Polycomb Group Protein EZH2 and Digestive System Tumor
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摘要 PcG蛋白在控制胚胎发育、X染色质失活、基因组印迹、干细胞自我更新以及肿瘤的发生、发展中发挥重要作用。EZH2是PcG蛋白的核心成分，在多种消化系肿瘤中表达增高，并与肿瘤的进展和预后差相关。本文就PcG蛋白的结构、功能以及EZH2在消化系肿瘤中的作用及其机制作一综述。 Polyeomb group proteins （PeG proteins） play important roles in the process of embryogenesis, X chromosome inactivation, genomic imprinting, stem cell self-renewal, as well as the development and progression of tumors. EZH2, the core component of PeG proteins, is overexpressed in various digestive system tumors, and has been linked to tumor progression and poor prognosis. In this review, we summarized the structure and function of PeG proteins, and the current knowledge of the contribution and mechanism of EZH2 in digestive system tumors.
作者 蔡干慧（综述） 陈晓宇（审校）
机构地区 上海交通大学医学院附属仁济医院消化内科上海市消化疾病研究所
出处 《胃肠病学》 2009年第5期299-302,共4页 Chinese Journal of Gastroenterology
关键词 PCG蛋白 EZH2 沉默子 转录 后成说 遗传 消化系统肿瘤 Polyeomb Group Proteins EZH2 Silencer Elements, Transcriptional Epigenesis, Genetic Digestive System Neoplasms
分类号 R735 [医药卫生—肿瘤] Q51 [生物学—生物化学]
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参考文献31

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胃肠病学
2009年 第5期

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