^60Coγ射线辐照神经移植后神经传导速度观察

Changes of nerve conduction velocity in ^60Co-irradiated rabbit sciatic nerve autograft after orthotopic replantation

目的探讨变性神经移植后神经传导速度情况。方法将30只大鼠分为实验组、对照组和正常组，实验组将^60Coγ射线先期辐射处理后的兔自体神经原位再植，对照组切除后不经辐射直接自体再植，正常组不做任何处理。再植术后4月、6月和8月分别对3组大鼠行电生理检查，观察神经传导速度。结果术后4月实验组的神经传导速度[（47．047±1．203）m／s]与正常组[（92．156±6．456）m／s]、对照组[（54．717±4．139）m／s]比较差异均有统计学差异（P〈0．05）；而术后6月和8月实验组与正常组、对照组比较，差异无统计学意义（P〉0．05）。结论长段自体神经（约3cm）经^60Coγ射线先期处理后再植．神经传导速度可逐渐恢复正常。

Objective To evaluate the changes of nerve conduction velocity in degenerative rabbit sciatic nerve authograft induced by ^60Co irradiation after orthotopic replantation. Methods A 30-mm-long segment was severed from normal adult rabbit sciatic nerve and exposed to ^60Co irradiation at the dose of 350 Gy to induce neural degeneration. The nerve segment was then replanted orthotopically, and the nerve conduction velocity was determined using electrophysiological test at 4, 6 and 8 months after the replantation. Results At 6, 8 months after the replantation, the nerve conduction velocity in the degenerative nerve autograft showed no significant difference from that in normal sciatic nerve （P〉0.05）. But at 4 months after the replantation, the nerve conduction velocity in the autograft was significantly lower than the normal velocity （P〈0.05）. Conclusion The nerve conduction velocity can be obtained by replantation of a long （3 mm） degenerative nerve segment due to ^60Co irradiation.