新疆胀果甘草化学成分研究

Studies on chemical constituents of glycyrrhiza inflata

目的:对新疆胀果甘草化学成分进行分离纯化和结构鉴定。方法:采用聚酰胺柱层析法对甘草根不同提取浸膏进行分离纯化并且利用光谱分析法鉴定化合物的结构。结果:从甘草根不同提取浸膏中得到5个单体化合物,化合物Ⅰ-Ⅲ被鉴定为甘草次酸、甘草苷和甘草查尔酮A,化合物Ⅳ和Ⅴ正在鉴定中。结论:利用聚酰胺柱层析法对新疆胀果甘草化学成分进行分离纯化所得到的化合物纯度高,从而对有效成分的含量测定、有效部位的筛选以及体内外药理实验铺垫了基础。

Objective： To isolate and purify the chemical contituents of Glycyrrhiz ainflata. Methods： Using column chromatography separation, purification, through spectral analysis of the structurer identification. Results： Five compounds from Glycyrrhiza inflata , Ⅰ-Ⅲ are Glycyrrhetic acid, Liquiritin and Licochalcone A. Conclusion： The method appeared to be simple, accurate. It provides a basis for determination of effect extracts in Glycyrrhiza inflata.