骨细粒棘球蚴动物模型放射性治疗的试验研究

The research on radiation therapy of the bone hydatid animal models

目的:探讨子午沙鼠骨细粒棘球蚴动物模型放射性试验治疗的效果及合适的放射剂量。方法:随机选择140只健康雄性SD子午沙鼠,鼠龄2～3个月,体重(40±5)g,建立子午沙鼠骨细粒棘球蚴动物模型。将接种成功的子午沙鼠骨细粒棘球蚴动物模型共72只随机分成4组,其中3组用不同放射剂量(40Gy/5次,50Gy/5次,60Gy/5次)进行治疗,每次间隔2d。放疗结束3个月后,观察大体变化并计算病灶处头节死亡率。结果:各组均有死亡病例,参与治疗的3组均有后爪肿胀病例,且中、高剂量组出现后腿脱毛及皮肤溃疡病例。各组存活沙鼠均未出现腹泻等放射性症状,一般行为均正常。各组头节死亡率差异有统计学意义(F=2.213,P<0.01)。结论:细粒棘球蚴头节死亡率在不同放射剂量上有明显的不同,且随着剂量的增大头节死亡率有上升的趋势。

Objective： To explore the effect of radiotherapy and proper radiation dose in the bone hydatid animal models of meriones meridianus. Methods： We chose 140 healthymale meriones meridianus with the age of 2-3 months old and the weight of （40±5） g to establish the bone hydatid animal models randomly. Then divided the successfully vaccinated meriones meridianus into 4 groups, in which 3 groups were carried on the radiotherapy with different radiation doses （40G y/5 times, 50G y/5 times, 60 Gy/5 times）. After the radiotherapy, the scolex death rate was observed under the microscope. Results： Every group has dead cases. 3 groups which participated the radiotherapy have the cases whose back leg emerge tumescence. The middle and high radiological dose groups have the cases whose back leg emerge depilation and skin ulcer. The result indicated that the difference of the scolex death rate between different groups have statistical Significance （P〈0.01）. Conclusion： The seolex death rate has significant deviation with different doses. The scolex death rate is proportional to the radiation dose.