甲状腺激素、白蛋白和血红蛋白联合检测在消化系统恶性肿瘤中的应用

Serum level of thyroid hormones,albumin and hemoglobin in patients with gastrointestinal cancer and its clinical significance

目的:探讨消化系统恶性肿瘤患者甲状腺激素、白蛋白和血红蛋白的变化。方法:84例消化系统恶性肿瘤患者(疾病组)采用电化学发光免疫分析仪检测甲状腺原氨酸(T3)、甲状腺素(T4)、游离甲状腺原氨酸(FT3)、游离甲状腺素(FT4)、促甲状腺激素(TSH)水平,同时检测白蛋白(ALB)、血红蛋白(HB)变化,50例健康体检者作为对照组。结果:疾病组与对照组比较,T4、FT4、TSH差异无统计学意义(P>0.05),ALB、HB差异无统计学意义(P>0.05),疾病组甲状腺激素T3、FT3降低(P均<0.05)。晚期恶性肿瘤患者与早期相比,T3、FT3、T4、FT4值均明显降低(P<0.05),TSH轻度降低,但差异无统计学意义(P>0.05),ALB、HB明显降低,差异有统计学意义(P<0.05)。结论:监测恶性肿瘤患者甲状腺激素水平和体内蛋白改变对判断疾病的严重程度及预后估计有积极意义。

Objective： To explore the changes of serum thyroid hormone, albumin and hemoglobin levels in patients with gastrointestinal cancer. Methods： Serum TT3, TT4, FT3, FT4 and TSH levels were measured with technique of electrochemiluminescence immunoassay in 84 patients with gastrointestinal cancer and in 40 healthy persons , serum albumin and hemoglobin were simultaneously measured. Results： Serum T4, FT4, TSH levels showed no significant change in patients with gastrointestinal cancer toward those in controls （P 〉0.05）, no significant change was observed of ALB and HB levels in patients （P〉0.05）, serum T3 and FT3 levels in patients with gastrointestinal cancer were significantly lower than those in controis （P d0.05）. Serum T3, FT3, T4 and FT4 levels in patients with late gastrointestinal cancer were notably lower than those in patients with early stage cancer （P〈0.05）. TSH levels of the patients in late stage were slightly lower, but not significantly. ALB and HB levels were notably lower, there were significant different （P〈0.05）. Conclusion. Detecting serum thyroid hormone levels combining with the measure of vivo proteins in patients with gastrointestinal cancer is helpful for the assessment of severity and prognosis of the disease.