富血小板血浆应用于创伤修复的研究进展

Research Advance on Application of Platelet-rich Plasma in Wound Repair——Review

血小板来源的生长因子作为一种生物活性物质,可以增强诸如趋化、细胞增殖、血管生成和细胞外基质沉积等创伤修复。富血小板血浆(PRP)是通常的血小板应用形式,激活后形成血小板胶,并释放包括PDGF、TGF、VEGF、IGF和EGF等在内的大量生长因子,对细胞的分化和有丝分裂活性产生极大的影响,并伴随整个创伤修复期。本文就富血小板血浆应用于创伤修复的理论基础和作用机制进行了总结,同时概述了有代表性的临床案例,并对这个创伤修复新方法的应用前景进行了分析和展望。

Platelets （Plts） have been shown to play a critical role in tissue repair mechanisms such as chemotaxis, cell proliferation, angiogenesis and extracellular matrix deposition. These effects are largely due to the contents of platelet granules, among which there are a number of important growth factors contributing to the wound repairing process. Platelet-rich plasma （PRP） has been traditionally used as a source of platelet growth factors （PGFs）. After connecting activator,platelet gel （PG） is formed and numerous PGFs such as PDGF, TGF, VEGF, IGF, and EGF are released. It is important in different stages of the wound-healing cascade and greatly influence mitogenic and cellular differentiation activities. The aim of this review is to present knowledge about properties of PRP and possibilities of using PRP in the treatment of wound, as well as the success of the clinical studies performed so far, finally the future of PRP therapies are also described.