术中快速冰冻病理检查诊断子宫内膜癌的价值

The Value of Intraoperative Frozen Section in Diagnosis of Endometrial Carcinoma

子宫内膜癌是女性生殖系统发生率很高的恶性肿瘤之一。快速冰冻病理是术中唯一诊断子宫内膜癌病理类型、病理分级及肌层侵袭深度、淋巴结转移情况的病理检查手段。结果可帮助在术中判断是否有必要实施详细的手术病理分期。众多研究表明,多种因素会影响快速冰冻病理检查的准确性,导致部分患者过度治疗或治疗不足,增加患者术后病率并影响其远期生存。综述术中冰冻切片在子宫内膜癌诊断中的准确性及影响因素。

Endometrial carcinoma is one of the most malignant tumors in female genital tract. Frozen section is the only intraoperative pathological method to diagnose the pathological type, tumor grade, myometrial invasion and lymphonode metastasis status which can help the surgeons to make the correct decision whether it is necessary for the patients to have full surgical staging. But there are many researches have shown that lots of factors can affect the accuracy of frozen section diagnosis thus leading to insufficient or over treatment. Patients＇ quality of life and long-term survival rate may be influenced. The objective of this review is to provide a summary on the accuracy of frozen section diagnosis and the clinical factors that affect the accuracy.