头孢曲松钠与含钙溶液配伍稳定性考察

Compatible Stability of Ceftriaxone Sodium with Calcium-containing Solutions

目的:研究头孢曲松钠与复方氯化钠注射液、乳酸钠林格注射液配伍的稳定性;并模拟体内头孢曲松钠血药峰浓度和静脉推注葡萄糖酸钙注射液离子瞬间高浓度时配伍液的稳定性。方法:采用高效液相色谱法测定配伍液中头孢曲松钠的含量,同时观察室温下配伍液外观、pH值、不溶性微粒变化。结果:头孢曲松钠与复方氯化钠注射液配伍后,0～2h澄清,2h后配伍液有肉眼可见的白色混浊,pH值升高,头孢曲松钠含量下降,不溶性微粒增加;与乳酸钠林格注射液配伍后,头孢曲松钠含量下降;模拟体内浓度进行配伍,外观无变化,头孢曲松钠含量稍有下降。结论:头孢曲松钠与复方氯化钠注射液、乳酸钠林格注射液不能配伍应用;静脉滴注头孢曲松钠达血药峰浓度后,成人是否可以静脉推注葡萄糖酸钙还有待进一步探讨。

OBJECTIVE： To study the compatible stability of Ceftriaxone Sodium with Compound Sodium Chloride In- jection or Sodium Lactate Ringer＇ s Injection and study the compatible stability of the simulated in vivo peak concentration of ceftriaxone sodium with instant high concentration of calcium gluconate ion injection. METHODS： The concentration of Cef- triaxone Sodium in the mixture was determined by HPLC, meanwhile, the changes of the mixture in appearance, pH value, and the insoluble particles at room temperature were observed. RESULTS： At 0--2 hours, the mixture of Ceftriaxone Sodium and Compound Sodium Chloride Injection was clear in appearance; however, at 2 hours, it was white cloudy macroscopically, and its pH valued increased, ceftriaxone sodium content decreased and insoluble particles increased. The eeftriaxone sodium content reduced when mixed with sodium lactate ringer＇ s injection. After mixing of simulated in vivo peak concentration of ceftriaxone sodium with instant high concentration of calcium gluconate ion injection, the appearance of the mixture was stable but the concentration of Ceftriaxone Sodium reduced slightly. CONCLUSION： Ceftriaxone Sodium can＇t be used in combina- tion with Compound Sodium Chloride Injection or Sodium Lactate Ringer＇ s Injection. Whether it is suitable to infuse calcium gluconate when ceftriaxone sodium （iv gtt） reached peak concentration remains to be confirmed in future study.