摘要
目的:比较噻吗洛尔、溴莫尼定、倍他洛尔、布林佐胺和曲伏前列腺素5种滴眼液的降眼压效果。方法:将原发性开角型青光眼、高眼压患者随机分为5组,其中噻吗洛尔组18例,溴莫尼定组13例,倍他洛尔组16例,布林佐胺组12例和曲伏前列腺素组10例,分别使用相应滴眼液,均治疗4周,测量用药前、后的眼压值。结果:5组患者用药4周眼压值均有明显下降,下降幅度依次为28.0%、28.9%、14.9%、16.1%和33.8%,且都产生了不同程度的副作用。结论:临床应根据各降眼压药的降眼压效果及副作用,合理选择使用。
OBJECTIVE: To evaluate the ocular hypotensive efficacies of five kinds of eye drops (Timolol, Brimonidine, Betaxolol, Brinzolamide, and travoprost). METHODS: Patients with primary open angle glaucoma (POAG) or ocular hyper- tension(OH) were randomly divided into 5 groups: Timolol(n = 18), Brimonidine(n = 13), Betaxolol(n = 16), Brinzolamide (n = 12) or travoprost(n = 10) . The course of treatment was 4 weeks for all the 5 groups. The intraocular pressure (IOP) before and after the treatment was measured. RESULTS: After treatment for 4 weeks, the IOPs in five groups decreased markedly, down 28.0%, 28.9%, 14.9%, 16.1%, and 33.8%, respectively, and all the 5 drugs resulted in adverse effects of different degree. CONCLUSION: The ocular hypotensive drugs should be used rationally by taking consideration of their oc- ular hypotensive efficacy and side effects.
出处
《中国药房》
CAS
CSCD
北大核心
2009年第17期1330-1332,共3页
China Pharmacy
关键词
治疗应用
青光眼
高眼压
药物疗法
Therapeutic use
Glaucoma
Ocular hypertension
Drug therapy