5种药物降眼压效果比较

Ocular Hypotensive Efficacy of Five Drugs:A Comparative Study

目的:比较噻吗洛尔、溴莫尼定、倍他洛尔、布林佐胺和曲伏前列腺素5种滴眼液的降眼压效果。方法:将原发性开角型青光眼、高眼压患者随机分为5组,其中噻吗洛尔组18例,溴莫尼定组13例,倍他洛尔组16例,布林佐胺组12例和曲伏前列腺素组10例,分别使用相应滴眼液,均治疗4周,测量用药前、后的眼压值。结果:5组患者用药4周眼压值均有明显下降,下降幅度依次为28.0%、28.9%、14.9%、16.1%和33.8%,且都产生了不同程度的副作用。结论:临床应根据各降眼压药的降眼压效果及副作用,合理选择使用。

OBJECTIVE： To evaluate the ocular hypotensive efficacies of five kinds of eye drops （Timolol, Brimonidine, Betaxolol, Brinzolamide, and travoprost）. METHODS： Patients with primary open angle glaucoma （POAG） or ocular hyper- tension（OH） were randomly divided into 5 groups： Timolol（n = 18）, Brimonidine（n = 13）, Betaxolol（n = 16）, Brinzolamide （n = 12） or travoprost（n = 10） . The course of treatment was 4 weeks for all the 5 groups. The intraocular pressure （IOP） before and after the treatment was measured. RESULTS： After treatment for 4 weeks, the IOPs in five groups decreased markedly, down 28.0%, 28.9%, 14.9%, 16.1%, and 33.8%, respectively, and all the 5 drugs resulted in adverse effects of different degree. CONCLUSION： The ocular hypotensive drugs should be used rationally by taking consideration of their oc- ular hypotensive efficacy and side effects.