摘要
目的:低密度脂蛋白(LDL)的氧化修饰在自身免疫疾病早发动脉粥样硬化过程中起重要作用。国外研究发现,在循环血和动脉斑块中氧化LDL(ox-LDL)能与抗心磷脂抗体的主要自身抗体β2-糖蛋白I(β2-GPI)结合成稳定的复合物。文中通过检测中国SLE患者血清β2-GPI/ox-LDL复合物水平,进一步探讨该复合物的临床诊断价值。方法:用ELISA法对47例系统性红斑狼疮(SLE)患者(SLE组)和42例健康对照者(对照组)检测比较。结果:SLE患者β2-GPI/ox-LDL水平显著高于对照组[(1.05±0.14)U/mlvs(0.79±0.11)U/ml,P<0.0001]。若以1 U/ml为临界值,SLE组中28例高于临界值(敏感性59.6%),对照组中仅4例异常(特异性90.5%)。2组β2-GPI/ox-LDL水平均与apoB和LDL呈显著正相关。结论:β2-GPI/ox-LDL对SLE有较高的敏感性与特异性,提示其潜在的临床诊断价值。
Objective： Oxidative modification of low density lipoprotein （LDL） plays an important role in the development of premature atherosclerosis in autoimmune disorders. Oxidized LDL （ox-LDL） reportedly forms stable complexes with β2-glycoprotein I （β2-GPI）, a major autoantigen for anticardiolipin antibodies, in circulation and the intima of atheroselerotie lesions. This study aims to investigate the serum β2-GPI/ox-LDL concentration in Chinese patients with systemic lupus erythematosus （SLE）, and clinical diagnostic value. Methods： The concentrations of β2-GPI/ox-LDL complexes were analyzed in 47 SLE patients and 42 healthy controls by ELISA. Results ： The serum β2-GPI/ox-LDL concentrations were significantly higher in the SLE patients than in the controls （ [ 1.05 ± 0.14 ] U/ml vs [ 0.79 ± 0.11 ] U/ml, P 〈 0. 0001 ）, elevated above the critical value 1 U/ml in 28 （59.6%） of the patients but only in 4 of the controls, with a significant positive correlation to LDL-C and apoB levels in both of the groups. Conclusion： β2-GPI/ox-LDL exhibited high sensitivity and specificity for SLE, suggesting its potential clinical value as a diagnostic marker for SLE.
出处
《医学研究生学报》
CAS
2009年第5期476-479,共4页
Journal of Medical Postgraduates
基金
国家自然科学基金资助项目(批准号:NSFC30872411)
