参松养心胶囊治疗室性早搏的疗效观察

Clinical study on treatment of ventricular premature beats with Shen Song Yang Xin Capsule

目的观察参松养心胶囊治疗不同病因室性早搏的疗效与安全性。方法选择心功能NYHAI～III级的室性早搏患者136例,采用多中心随机对照为治疗组(76例)和对照组(60例),治疗组口服参松养心胶囊4粒,3次/d;对照组口服心律平150mg,3次/d,疗程4周。观察2组患者室性早搏的总有效率、症状改善率及安全性。结果治疗组总有效率为92.1%,症状改善率为86.8%;对照组总有效率为73.3%,症状改善率63.3%。2组比较差异有统计学意义(P<0.05),治疗组室性早搏疗效和临床症状改善优于对照组。结论参松养心胶囊对不同病因的室性早搏有明显疗效,且无严重不良反应。

Objective To investigate the efficicay and safety of Shen Song Yang Xin Capsule in treating ventricular premature beats（VPB）. Method 136patients with frequent ventricular premature beats were enrolled and randomly assigned into two groups. 76 patients in treatment group treated with Shen Song Yang Xin Capsule （4 capsules,three times per day） and 60 patients in control group treated with propafenone （150 rag, three times per day） , the therapeutic course for both groups were 4 weeks. The efficacy on VPB, improvement of main clinical symptoms and safety were observed in two groups. Results The general efficacy on VPB in treatment group was significantly higher than that in control group （ 92. 1% vs 73.3% ,P 〈0.05） ; The effective rate of improving the main clinical symptoms in treatment and control group were 86. 8% and 63.3%, respectively. The difference between two groups was significant （ P 〈 0. 05 ）. Conclusion Shen Song Yang Xin Capsule has obvious efficacy for treatment of VPB and no serious side effects.