尿白介素-8在狼疮性肾炎活动性病变中的临床意义

Clinical significance of urinary interleukin8 on active lupus nephritis

目的探讨能准确合理地评估狼疮性肾炎（ＬＮ）活动的客观指征。方法采用ＥＬＩＳＡ夹心法在ＬＮ活动期和环磷酰胺（ＣＴＸ）加激素冲击治疗后８周测定患者晨尿白介素８（ＩＬ８）的水平，以治疗稳定期的ＬＮ患者作对照。结果发现ＬＮ活动期患者尿ＩＬ８水平显著高于稳定期ＬＮ患者（３２５６±１２６７ｖｓ１４４４±７２５ｐｇ／ｍｇ．Ｃｒ，Ｐ＜００５）；ＣＴＸ加激素治疗８周后的活动性ＬＮ患者，治疗后ＩＬ８水平显著低于治疗前（１９６７±９０４ｖｓ３２５６±１２６７ｐｇ／ｍｇ．Ｃｒ，Ｐ＜００５），同时狼疮活动的临床症状和生化明显好转。结论提示尿ＩＬ８水平与狼疮性肾炎的病变活动密切相关，并可作为ＬＮ活动和预后评估的一个重要参数。

bjective To assess reasonably an objective index of active lupus nephritis (LN). Methods IL8 levels of morning urine were determined by sandwichELISA within LN active period and 8 weeks after treating with cyclophosphamide (CTX) adding steroid pulsation, treatment of stable LN was used as a control. Results IL8 level of active LN was significantly higher than that of stable LN (325.6±126.7 vs. 144.4±72.5 pg/mg.Cr, P<005);In CTX adding steroid pulsaltion group, Il8 level of posttreatment was significantly lower than that of pretreatment (1967±904 vs. 3256±1267 pg/mg.Cr, P<005), meanwhile the clinical symptoms and biochemical parameters were improving obviously. Conclusion IL8 is closely related to the activity of LN and may be used as an index to assess tha activity of LN.