血液灌流联合血液透析救治急性重型中毒的疗效观察

The application of Hemoperfusion and Hemodialysis in rescuing patients with critical acute poisoning

目的观察血液灌流联合血液透析对救治急性重型中毒患者的疗效。方法急性药物或食物中毒昏迷患者44例，按治疗方法不同将病例分为治疗组（n=28）与对照组（n=16）。对照组患者常规给予洗胃、吸氧、药物解毒和生命支持等治疗，治疗组患者除上述处理还进行血液灌流和血液透析治疗，观察两组患者昏迷时间、住院天数、治愈率、死亡率、并发症。结果治疗组治愈27例，死亡1例，对照组治愈11例，死亡5例。治疗组昏迷时间、住院天数、死亡率、并发症发生率明显少于对照组（P〈0．01），治愈率高于对照组（P〈0．01）。结论血液灌流联合血液透析可迅速清除体内的药物或毒物，明显缩短病程、减少并发症，提高急性重症中毒患者的生存率。

Objective To observe the clinical effects of hemoperfusion （HP） plus hemodialysis （HD） on the patients with critical acute poisoning. Methods 44 cases in coma,which got critical acute drug or food poisioning,were divided into groups,the cure group（ n = 28 ） and the control group （n = 16）. The control group was given gastrolavage, oxygen inhalation, drug tetoxification and basic life-support treatment, on this basis, the cure group was given HP and HD. The duration of coma, the average hospital day, the cure rate and the death rate were observed, and compared between the two groups. Results 27 cases were cured and 1 case died in the cure group, while 11 cases were cured and 5 cases died in the control group, contrast to the control group,it is a singnifieant decrease on the duration of coma, The average hospital day and the death rate in the cure group, and it is supperial to the control group （ P 〈 0. 01 ）. Conclusion HP and HD is one of the efficient measures to the rescuing patients with critical acute poisoning, because it can clear the drug and food poison quickly, shorten the course of disease and reduce complication,improve the survival rate of patients with critical acute poisoning.