摘要
的了解扩张后皮肤慢性损害的动态修复过程。方法选用７ｋｇ左右的狗为实验动物。实验分为扩张后即时、１个月、３个月、６个月、１年及对照组共６组，采用超微结构的观察及胶原定量分析等研究手段。结果发现扩张刺激可致皮肤慢性损害，早期修复表现为成纤维细胞功能活跃，胶原合成增加；随着时间的延长，成纤维细胞结构渐趋稳定，密体、密斑消失，胞浆减少，微粒纤细；大部分胶原纤维恢复正常的网状结构，但部分胶原纤维排列紊乱，呈“漩涡状”排列，似“瘢痕样”改变。结论扩张可致皮肤慢性损害。
Objective To observe the dynamic repairing process of skin chronic injury due to expansion.Method Domestic dogs (7 kg) used in this study were divided into six groups: immediate, 1 month, 3 months, 6 months and 1 year after expansion as well as the control group. Dermal ultra structure observation and analysis of collagen were applied. Result The stimulation from expansion may lead to chronic skin injury, the microfilament in fibroblast was fragile, and the features of myofibroblast were absent. Most of the collagen fibers were returned to reticular arrangement along with time, only few remained irregular and sparse in arrangement. Conclusion The chronic injury of the subcutaneous tissue due to expansion could recover spontaneously, but the recovery was not tissue regeneration.
基金
国家自然科学基金
