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帕米膦酸二钠的合成 被引量：2

Preparation of Pamidronate Disodium
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摘要 3-氨基丙酸在95～100℃条件下,与85%磷酸和三氯化磷反应,经9mol/L盐酸水解后得到帕米膦酸,再经氢氧化钠水溶液成盐即可得到帕米膦酸二钠,总收率约37%。 Pamidronate disodium was synthesized from 3-aminopropionic acid by reaction with phosphoric acid and phosphorus trichloride at 95 - 100 ℃, and then hydrolysis with 9 mol/L hydrochloric acid to give pamidronic acid, followed by salification with sodium hydroxide solution with an overall yield of about 37 %.
作者 李鹏
机构地区 辽宁省葫芦岛市天成药业有限公司
出处 《中国医药工业杂志》 CAS CSCD 北大核心 2009年第6期406-407,共2页 Chinese Journal of Pharmaceuticals
关键词 帕米磷酸二钠 高钙血症 合成 pamidronate disodium hypercalcaemia synthesis
分类号 R979.9 [医药卫生—药品]
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共引文献20

同被引文献29

  • 1蒋利华.骨质疏松症药物治疗进展[J].中国药业,2006,15(4):3-5. 被引量：4
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  • 3Kieczykowski G R, Jobson R B, Melillo D G, et al. Preparation of ( 4-amino-l-hydroxybutyli- dene) bisphosphonic acid sodium salt, MK-217 (alendronate sodium). An improved procedure for the preparation of 1-hydroxy-1, 1-bisphos- phonic acidsl-J]. Journal of Organic Chemistry, 1995, 60(25): 8 310-8 312.
  • 4Palma E, Correia Joa o D G, Campello M P C, et al. Bisphosphonates as radionuclide carriers for imaging or systemic therapy[J]. Molecular Bio- systems, 2011, 7:2 950-2 966.
  • 5Kumar D, Kumar V, David G, et ah Evaluation of biodistribution by local versus systemic admin- istration of 99mTc-labeled pamidronateFJ]. Jour- nal of Orthpaedic Science, 2006, 11: 512-520.
  • 6Kumar V, Howman G, Robert B, et al. Is gg~Tc-labeled pamidronate a better agent than 99mTc-medronate for bone imaging? [J]. Nuclear Medicine Communications, 2007, 28(2): 101- 107.
  • 7郭郡浩,姚茹冰,赵智明,刘玉秀,郑均,蔡辉.利塞膦酸钠胶囊治疗绝经后骨质疏松症[J].医学研究生学报,2009,22(2):154-157. 被引量：14
  • 8焦建宇,冯怡民,史守镛,邢玉仁.阿仑膦酸钠的合成[J].中国医药工业杂志,1998,29(5):202-203. 被引量：8
  • 9李心欣,李成浩.^(99)锝-亚甲基二膦酸盐在类风湿性关节炎中的应用[J].实用药物与临床,2010,13(1):69-70. 被引量：15
  • 10孟迅吾.双膦酸盐治疗原发性骨质疏松症[J].中华内分泌代谢杂志,1998,14(6):345-347. 被引量：11

引证文献2

中国医药工业杂志
2009年 第6期

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