阿立哌唑与利培酮对血清催乳素及体质量的影响

Aripiprazole and risperidone on serum prolactin and the impact of body mass

目的:比较阿立哌唑与利培酮治疗女性首发精神分裂症的疗效及对血清催乳素(PRL)水平及体质量的影响。方法:70例女性首发精神分裂症患者分为阿立哌唑组和利培酮组,每组35例。分别给予阿立哌唑和利培酮治疗8周。以阳性与阴性症状量表(PANSS)及治疗中出现的症状量表(TESS)评估疗效和不良反应,同时检测两组的血清PRL水平。结果:两组间PANSS各项评分及临床有效率差异无显著性(P>0.05);阿立哌唑组在PRL水平改变及体质量增加方面优于利培酮组(P<0.05或P<0.01),泌乳、月经紊乱明显少于利培酮组。结论:两药治疗女性精神分裂症均有较好疗效,以阿立哌唑对内分泌影响较小,更适合于女性患者。

Objective：Comparison of aripiprazole and risperidone in the treatment of female first-episode schizophrenia and the effect on serum prolaetin （PRL） levels and the impact of body mass. Method ：70 cases of female first-episode schizophrenia patients were divided into aripiprazole groups and risperidone groups for eight weeks. Positive and negative symptoms scale （PANSS） was adminstered to assess the efficacy and the treatment of symptoms scale （TESS） was applied to assess the adverse reactions, at the same time the level of serum PRL was examined in the two groups. Results： There is no significant difference in the score of the PANSS and efficacy between the two groups（ P 〉 0.05 ）. Aripiprazole did not affect PRL and body mass. while aripipraz^le group showed less impact on lactation,menstrual disorder than the risperidone group. Conclusion：The two-drug treatment of female patients with schizophrenia have a better effect, but aripiprazole is more suitable for female patients.