内皮素与猪原位肝移植术循环功能损害的关系

Changes of plasma endothelin in surgery of orthotopic liver transplantation

目的：为探讨ＥＴ与猪原位肝移植（ＯＬＴ）术循环功能损害的关系，方法：观察了一组１２例ＯＬＴ术的猪血浆ＥＴ的变化，同时测定血流动力学指标的变化，结果：ＥＴ在猪ＯＬＴ术的无肝缺血期开始升高，再灌注后进一步升高；血浆ＥＴ水平与再灌注后心肌损害和血流动力学紊乱有关（ＥＴ与ＭＡＰ，ＳＶＲ，ＰＶＰ，ＰＡＷＰ／ＣＯ，ＳＶ）等呈正（负）相关关系。

Objective:To reseach the relationship of ET and cardiovascular dysfunction during OLT.Methods:Twelve pigs undergoing OLT were studied.Results:It was found that the plasma ET value significantly increased (P<001)during venous occlusion and increased futher more after reperfusion(P<0.01);There was a relation of the ET values and mean artrial pressure, systmic vascular resistance and pulmonary arterial wedge pressure after reperfusion .Conclusion:Obove shows that ET is one of major factors which brings about cardiovascular dysfunction after reperfusion in OLT.