脊髓小胶质细胞内信号p38丝裂原活化蛋白激酶在神经病理性疼痛的作用

The effect of microglial signaling p38MAPK on neuropathic pain

证据表明小胶质细胞在神经病理性疼痛中扮演着重要的角色。神经损伤后，小胶质细胞内p38丝裂原活化蛋白激酶（p38 mitogen activated protein kinase，p38MAPK）激活，致小胶质细胞产生各种生物活性物质，引发痛觉超敏。小胶质细胞内p38MAPK在神经病理性疼痛的发生和发展中起重要作用，p38MAPK及其亚型有望成为治疗神经病理性疼痛的新靶点。

Emerging evidences indicate that microglia plays a critical role in the pathogenesis of neuropathic pain. Previous evidences suggest that the activation of p38MAPK signaling pathway in hyperactive microglia in the dorsal horn of spinal cord involves in the neuropathic pain. Present findings shows that p38MAPK is activated in the spinal microglia after nerve injury and con- tributes importantly to the development and maintenance of neuropathic pain.