泌尿系结石患者体外震波碎石前后血清和尿液SST,SOD,6-OH和EGF变化的研究

Changes of SST,SOD,6-OH and EGF in Serum and Urine of Patients with Urinary Calculi before and after ESWL

应用放射免疫技术,对45例泌尿系结石患者体外震波碎石(ESWL)前后血清和尿液生长抑素(SST)、超氧化物歧化酶(SOD)、6-酮(6-OH)和表皮生长因子(EGF)水平进行了检测。结果:血清SST、SOD在ESWL后明显降低,6-OH升高,EGF无明显变化。尿液SST降低,6-OH显著升高,SOD和EGF无明显变化,血清和尿液的SST(r=0.458,P<0.05),6-OH(r=0.461,P<0.05)均呈正相关。结果提示联合测定血清和尿液中上述物质对研究ESWL引起泌尿系组织细胞及一些激素的改变有—定临床意义。

The levels of somatostatin(SST) ,superoxide dismutase(SOD) ,6-OH and epidermal growth factor (EGF) in the urine and serum of 45 patients with urinary calculi were determined with RIA before and after extracorporeal shockwave lithotripsy(ESWL). The results showed that:serum SST and SOD were lower,6-OH elevated significantly,but there were no changes of EGF after ESWL;urine SST was lower, 6-OH elevated markedly,but there were no changes of SOD and EGF after ESWL. The urine and serum SST,as well as 6-OH were positively correlated. It is suggested that combining determination of these factors in the serum and urine are important to study changes of urinary histology and some hormone caused by ESWL.