威特肾肿灵对IgA肾病的疗效研究

A Study on Treatment of Weiteshenzhongling on IgA Nephropathy

用四氯化碳引起鼠类中毒性肝硬变，进而导致ＩｇＡ肾病，同时运用脂多糖，使系膜区补体Ｃ３沉着。在此模型基础上，使用威特肾肿灵治疗，观察其对ＩｇＡ肾病的治疗效果。研究发现，威特肾肿灵有降低血清ＩｇＡ和ＩｇＧ，减少其在肾小球系膜区沉着，抑制补体的激活，减轻局部组织损伤的作用。

IgA nephropathy was caused by cirrhosis that had been reduced by carbon tetrachloride in mice. Using lipopolysaccharide reduced the deposit of C 3 in mesangium and increased the local inflammatory reaction. On the base of the experiment, Weiteshenzhongling was used to treat IgA nephropathy in mice. The result made clearly that Weiteshenzhongling could decrease the amount of IgA, IgG in serum and the deposit of IgA, IgG in mesangium, inhibited the action of complement, and lightened the injure in local tissue.