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正常孕妇和妊高征患者血浆内皮素及血清一氧化氮的变化 被引量:2

Changes of Plasma Endothelin and Serum Nitric Oxide in Normal Pregnancy and Pregnancy-induced Hypertension
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摘要 目的:探讨内皮素(ET)、一氧化氮(NO)及两者关系在正常妊娠生理和妊高征病理生理变化中的作用。方法:应用放射免疫法和Greiss法测定20名正常未孕妇女(NNP组)、20名正常孕晚期妇女(NLP组)和35名妊高征患者(PIH组)的血浆ET和血清NO值,并加以比较。结果:NLP组与NNP组相比,血浆ET和血清NO水平均显著升高(P<0.01),但二者比值无明显变化(P>0.05)。中、重度PIH组与NLP组相比,ET水平显著升高(P<0.01),NO水平显著降低(P<0.01)。各PIH组ET/NO值均显著高于NLP组(P<0.01)。中、重度PIH组ET/NO值显著高于轻度PIH组(P<0.01)。在中、重度PIH组中,ET与NO呈显著负相关。结论:ET增高、NO降低,二者间平衡失调在妊高征病理生理变化中起重要作用。 Objective: This paper was designed to investigate the role of nitric oxide (NO) and endothelin (ET) on normal pregnancy and pregnancy-induced hypertension (PIH). Methods: We studied 35 women with PIH (PIH group), 20 normal late pregnant women (NLP group) and 20 normal non-pregnant women (NNP group). The concentrations of NO and ET in serum and plasma were determined by Greiss reaction and radioimmunoassay. Results: The levels of ET and NO were significantly higher in NLP group as compared with NNP group ( P <0 01), but ET/NO ratio did not change obviously ( P >0 05). The ET level increased markedly and NO level decreased apparently in moderate and severe PIH group in comparison with those in NLP group ( P <0 01). The ET/NO ratio was significantly higher in each PIH group than that in NLP group ( P <0 01). The ET/NO ratio in moderate and severe PIH group was considerably higher than that in mild PIH group ( P <0 01). In moderate and severe PIH group, the ET level was negatively related to NO level. Conclusions: Decreased NO level, increased ET level, and the imbalance between them might play important roles in the pathogenesis of PIH.
出处 《中国医科大学学报》 CAS CSCD 北大核心 1998年第3期283-286,共4页 Journal of China Medical University
关键词 内皮素 一氧化氮 妊娠高血压 综合征 nitric oxide endothelin pregnancy-induced hypertension
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